MicroRNA-145 hinders carotid plaque growth via suppression of tumor growth factor-β receptor type II and autophagy.
Plaque erosion is increasingly recognized as a critical pathological mechanism in acute coronary syndrome. In this study, we found that microRNA-145 (miR-145) levels were significantly reduced in plaques with grade III-IV stenosis compared with controls. Using an apoE-/- mouse model fed a high-cholesterol diet, we demo...