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Author

Jun-Wen Wang

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Open access Sep 2026

Rtel1 in hypothalamic oxytocin neurons regulates oxytocin output and social behaviors in mice

RTEL1, a DNA helicase that resolves G-quadruplexes to maintain telomere and genome stability, has emerged as a candidate autism spectrum disorder risk gene, but its neural functions remain unknown. Here, we show that Rtel1 haploinsufficiency in mice impairs social novelty and increases marble burying and anxiety-relate...

Jun-Wen Wang, Xia-Qing Wang, Zi-Long Qiu · 0 citations
Open access Oct 2026

Juvenile AAV-Mediated MEF2C Gene Replacement Ameliorates Selected Phenotypes in Mef2c-Haploinsufficient Mice

MEF2C haploinsufficiency syndrome is a severe neurodevelopmental disorder for which no disease-directed treatment is available. We investigated whether neuron-directed adeno-associated virus (AAV) delivery of a functional MEF2C coding sequence during the juvenile period could modify disease-relevant phenotypes in mice...

Zhuo-Lei Jiao, Cheng-Jie Yu, Tian-Shu Li et al. · 0 citations

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