Lactylation-driven mitochondrial dysfunction promotes diabetic myocardial fibrosis via impairing mitophagy and activating TGF-β1
This study aimed to investigate the role and mechanisms of lactate-derived protein lactylation in promoting myocardial fibrosis in diabetic cardiomyopathy (DCM). We hypothesized that lactylation contributes to fibrosis through dual pathways: impairing PINK1/Parkin-mediated mitophagy and epigenetically activating the TG...