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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Junyan Wang

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Review Open access Sep 2026

Astragaloside IV as a Multi-Target Neuroprotective Candidate in Ischemic Stroke and Cerebral Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Perspectives

Ischemic stroke (IS) and cerebral ischemia-reperfusion injury (CIRI) involve overlapping but temporally distinct pathological processes, including oxidative stress, neuroinflammation, regulated cell death, impaired neurovascular repair, and systemic risk-factor regulation. Astragaloside IV (AS-IV), a major active sapon...

Yi-Lin Nan, Jun-Yan Wang, Yan-Yan Chen · 0 citations
Aug 2026

PGAM5-mediated VDAC1 oligomerization Facilitates Ponatinib-Induced Cardiotoxicity via Disrupting the Mitophagy-Mitochondrial unfolded protein response Synergistic Defense Crosstalk.

These findings identify the PGAM5/VDAC1 axis as a key mechanism linking ponatinib stress to coordinated failure of MQC in the heart and targeting PGAM5-dependent VDAC1 oligomerization may represent a potential strategy for limiting ponatinib-associated cardiotoxicity.

Yu-Yue Li, Dandan Yuan, Haitao Zhou et al. · 0 citations

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