Open access
Aug 2026
SGLT2 inhibition, uric acid and inflammation in glycemic burden-related progression of cardiac autonomic neuropathy in type 2 diabetes mellitus: insights from machine learning and mediation analysis
SGLT2 inhibitor use is significantly associated with a lower risk of DCAN deterioration in T2DM patients, whereas elevated HbA1c levels correlate with disease progression, potentially involving pathways of exacerbated uric acid metabolism and systemic inflammation.
Jing-Jing Wang, Jie Hu, Wu Dai et al.
· Frontiers in Endocrinology · 0 citations