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Sep 2026

Subpicogram-Level Quantification of Trace Biomarkers Using an Automated High-Sensitivity Chemiluminescence Immunoassay Technology Based on a Novel Substrate Enhancement Strategy

Trace biomarkers showed great potential for improving the diagnosis and monitoring of various diseases. However, the sensitivity of the current high-throughput detection platforms is limited, posing a significant challenge for the reliable measurement and clinical application of trace biomarkers. We developed an auto...

Ke-Xin Li, Zhuo-Nan Duan, Ke Li et al. · 0 citations
Open access Oct 2026

Performance Characteristics for Flow Cytometric Enumeration of Peripheral Blood Lymphocyte Subsets under Harmonized Laboratory Conditions: A Multicenter Study.

BACKGROUND Flow cytometric enumeration of peripheral blood lymphocyte subsets (EPBLS) is essential for disease management, yet standardized validation criteria are lacking. We defined key performance characteristics under harmonized conditions to support criteria development. METHODS 205 whole blood samples and 54 qu...

Lin Xiao, Yuan Wang, Yi Li et al. · 0 citations
Open access Jul 2026

Integrated Single-Strand DNA Capture and Haplotype-Guided Variant Calling Platform for Non-Invasive Prenatal Testing of Monogenic Disorders

An accurate and robust NIPT-MD platform for monogenic disorders, with high concordance to invasive testing validated in a retrospective cohort of 35 clinical cases, holds promise for clinical application in managing families at high risk of monogenic diseases.

Jie Shen, Wei Liu, Li Lu et al. · 0 citations

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