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Oct 2026

Synthesis and Characterization of Aminooxy Click Chemistry-Mediated Bis -Conjugates of siRNAs and Evaluation of Their RNAi Activity

Previously, we used an aminooxy click chemistry (AOCC) strategy to introduce pairs of ligands into oligonucleotides during solid-phase synthesis by using nucleoside and non-nucleoside building blocks. However, the standard oligonucleotide synthesis conditions were incompatible with the incorporation of certain comple...

Dhrubajyoti Datta, Mark Neil Tolentino, Mimouna Madaoui et al. · 0 citations

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