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Author

Junfeng Guo

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Open access Jul 2026

Triptolide targets JUN to reverse cisplatin resistance of ovarian cancer: insights from single-cell transcriptome analysis and machine learning validation

This study developed a comprehensive strategy integrating computational predictions with in vitro experimental validations that reverses CDDP resistance in PROC by downregulating JUN, which dismantles intracellular pro-survival networks.

Chen Wang, Junfeng Guo, Taiyang Ye et al. · 0 citations