Author

Jung-Hoon Shin

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Sep 2026

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.

Using single-nucleus RNA sequencing across 109 human and 22 mouse samples spanning dorsal and ventral striatum, a comprehensive atlas of subregional neuronal specialization is provided, suggesting divergent pharmacological targets, connectivity, and disease mechanisms.

Raleigh M. Linville, Benjamin T. James, K. Galani et al. · Cell · 2 citations

#reinforcement learning Open access Sep 2026

Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices

Everyday decisions depend on associations between sensory stimuli, actions, and outcomes. The striatum supports these sensorimotor associations through dopamine-dependent plasticity. Recent work has characterized a local striatal microcircuit in which cholinergic interneurons (CINs) modulate dopamine release via activa...

Hannah C. Goldbach, Rachele Rimondini, Evan S. Swanson et al. · Nature Communications · 0 citations