Open access
Aug 2026
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation
The TAM receptor AXL is identified as a molecular transducer that couples Aβ sensing to the regulation of autophagy and neuroinflammation in astrocytes and proposed the AXL-ICD/SIRT2 axis as an effective therapeutic target to reduce Aβ burden and neuroinflammation in AD.
T. Kim, Mridula Bhalla, Uiyeol Park et al.
· bioRxiv · 0 citations