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Junxia Cao

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Open access Aug 2026

RACK1 maintains mouse hematopoietic stem cells by directly binding to and stabilizing LDB1

Single-cell RNA sequencing indicates that adulthood Rack1 deletion in type I interferon-I-responsive cells leads to aberrant lineage-geneset-scores of transcriptional HSCs and the emergence of stressed HSCs, and Mechanistically, RACK1 prevents HSC loss through maintaining the protein level of LDB1.

L. Deng, Junjie Du, Zhengqiu Xu et al. · 0 citations