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Justin Lack

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Open access Oct 2026

Thymic stromal defects and immune dysregulation in hypomorphic Rag deficiency: implications for hematopoietic cell transplantation.

BACKGROUND Thymic epithelial cells (TEC) are essential for positive and negative selection during T-cell development. Hypomorphic RAG deficiency is characterized by T-cell lymphopenia and an increased risk of infections and autoimmunity. However, whether abnormalities of TEC composition and function also contribute to...

Francesca Pala, C. Oguz, Cristina Corsino et al. · 0 citations

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