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Sep 2026

Psychosocial treatment with or without antipsychotic medication in first-episode psychosis: What have we learned from the STAGES trial about the risks and benefits?

STAGES trial was a triple-blind noninferiority trial that investigated intensive psychosocial treatment with or without low-dose antipsychotics in young people with first-episode psychosis with a short duration of untreated psychosis, who were low-risk and had stable family support. Participants received cognitive beha...

K. Allott, S. Chopra, B. O'Donoghue et al. · 0 citations
Sep 2026

Cognitive profiles in first-episode psychosis: The impact of genetics, environment, and cognitive reserve as risk and protective factors.

BACKGROUND Cognitive impairment is a core but heterogeneous feature of first-episode psychosis (FEP). Genetic liability, environmental exposures, and protective mechanisms such as cognitive reserve (CR) have been implicated in cognition. We examined whether cognitive profiles in FEP differed according to polygenic risk...

M. F. Forte, F. D. Rabelo-da-Ponte, Derek Clougher et al. · 0 citations

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