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Author

K. Balaji

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2 papers indexed here

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Open access Sep 2026

Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) increases the availability of free iron, resulting in ferroptosis of macrophages to facilitate its survival and dissemination. A critical factor for elevated levels of labile iron is the overt accumulation of nuclear receptor coactivator 4 (NCOA4), which promotes autophagic degradation...

Smriti Sundar, R. S. Rajmani, K. Balaji · 0 citations
Jul 2026

Mechanisms regulating ferritinophagy during infection with Mycobacterium tuberculosis induces ferroptosis and orchestrates TB pathogenesis 2255488

It is found that pharmacological inhibition or knockdown of PRMT5 rescues iron homeostasis, concomitantly decreasing lipid peroxidation and ferroptosis in vitro and in vivo, thereby restricting Mtb burden.

K. Balaji, Smriti Sundar, R. S. Rajmani · 0 citations

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