Open access
Sep 2026
Phosphoinositides protonation states dictate AKT1 binding with membrane
The findings establish a direct connection between phosphoinositide protonation equilibria, binding energetics, and AKT1 lipid specificity and highlights the degenerate roles of secondary messenger lipids as a function of membrane environments.
K. Jha, Meghadeepa Sarkar, K. Baratam et al.
· bioRxiv · 0 citations