Summary Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic form of heart disease often caused by mutations in desmosomal proteins. We carried out single-nucleus RNA sequencing (snRNA-seq) on 11 non-failing and 8 ARVC patient right ventricular samples and transcriptionally profiled 139,347 nuclei....
B. Simonson, M. Chaffin, Yasmine Guedira et al.· iScience· 0 citations
Age is the greatest risk factor for cardiovascular diseases, including heart failure (HF), which is a leading cause of morbidity and mortality. While left ventricular fibrosis, hypertrophy and decreased contractility are associated with cardiac aging, age is not sufficient for HF development. Despite diminished cardiom...
Samaneh Ekhteraei-Tousi, Rosa Doñate Puertas, M. Youness et al.· Aging and Disease· 0 citations
AIMS
Mitral regurgitation (MR) pathophysiology involves increased serotonin (5-HT) receptor (HTR) expression and signaling, together with reduced 5-HT transporter (SLC6A4) expression in mitral valve interstitial cells (MVIC). The mechanosensitive calcium channels, PIEZO1 and PIEZO2, regulate cellular responses to a var...
Stanley J. Stachelek, Emily J. Hauber, Xiao-Qiu Yang et al.· Cardiovascular Research· 0 citations
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