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K. Bucholz

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Open access Oct 2026

Polygenic Risk Profiles and the Manifestations of Alcohol Use Disorder and Related Outcomes

ABSTRACT Background Research suggests that multiple genetically influenced pathways of risk impact alcohol use disorder (AUD), including externalizing (disinhibition, behavioral undercontrol), internalizing (negative affect, depression), and alcohol‐specific (physiological response to alcohol) factors. This study exami...

G. Dash, F. Aliev, S. Kuo et al. · 0 citations
Open access Sep 2026

Socioeconomic disparities in substance use disorder prevalence and severity across the life course

Gradients across socioeconomic status (SES) exist across most health conditions. While there has been significant attention devoted to the relationship between SES and physical and mental health, less research has examined how these relate to substance use disorders (SUD). In the current study, we use data from the pro...

Peter B. Barr, Megan E. Cooke, S. Kuo et al. · 0 citations
Open access Aug 2026

The Influence of Spousal Genotype on Alcohol Problems in Marriage

Having a spouse with higher PGSPAU was associated with higher AUDcrit and the social genetic effect of spousal PGSPAU was stronger among male target individuals, highlighting the potential importance of social genetic effects for understanding the pathways from genotype to alcohol use disorder.

S. Kuo, V. McCutcheon, F. Aliev et al. · 0 citations

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