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Author

K. Carillo

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Open access Sep 2026

Engineered subtilisin protease degrades active KRAS in cancer cells leading to differential cell targeting

Controlling aberrant RAS signaling has been the subject of intensive efforts aimed at developing specific RAS inhibitors, small molecules that promote RAS degradation, and monobodies that inhibit RAS activity. Direct proteolytic degradation of RAS by site-specific proteases has received considerably less attention. A n...

T. Fuerst, M. Goldstein, Betty W. Chu et al. · 0 citations
Open access Aug 2026

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

The NTD is established as a critical regulator that enhances Ca2+ responsiveness by shifting Sorcin’s conformational equilibrium toward the active state and suggest that flexible N-terminal extensions regulate signaling within the penta-EF-hand protein family.

Qiushi Ye, Angela Wu, K. Carillo et al. · 0 citations
Open access Aug 2026

Benchmarking Deep Learning Predictions of Mutation-Induced Fold Switching

A systematic NMR-characterized dataset of mutants of the GA/GB model fold-switching system is presented and it is found that this benchmark revealed variable and position-dependent performance across methods, with certain AlphaFold2-based algorithms able to predict mutant effects at individual sites, indicating some un...

Nathaniel R. Felbinger, K. Carillo, Yihong Chen et al. · 0 citations

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