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Author

K. Chaprov

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Open access Oct 2026

Synucleins deficiency alter dopamine- and glutamate-induced calcium signal in neurons and astrocytes.

Proteins α-, β-, and γ-synuclein in brain distributed predominantly in presynaptic terminals suggesting their role in regulating neurotransmitter release and signal transduction. Misfolded α-synuclein is involved in the pathology of Parkinson's disease which is characterized by the loss of dopaminergic neurons and the...

A. Fedulina, A. Baev, Alexey V. Emelyanov et al. · 0 citations
Open access Aug 2026

Lack of synucleins induces an alteration of lipid peroxidation in the brain.

Family proteins - α-, β, γ-synucleins shown to play important roles in metabolism, signal transduction and dopamine handling. Aggregated α-synuclein is neurotoxic and involved in pathogenesis of Parkinson's disease. The mechanism toxicity of aggregated α-synuclein includes lipid peroxidation, oxidative stress and ferro...

A. Fedulina, E. Seryogina, K. Chaprov et al. · 1 citation

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