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Review Oct 2026

Abstract B059: Patient-reported barriers to clinical trial enrollment: A site-level analysis of DCP-001 non-enrollees at an academic medical center

Understanding why eligible patients with cancer decline clinical trial participation is critical to developing targeted accrual interventions. DCP-001 is a National Cancer Institute (NCI) Division of Cancer Prevention protocol within the NCI Community Oncology Research Program (NCORP). The protocol systematically...

J. Kahn, M. Beauchemin, Erik Harden et al. · 0 citations
Open access Oct 2026

Somatic-to-germline concordance rates in clinically actionable cancer predisposition genes.

540 Background: Somatic tumor testing increasingly identifies pathogenic variants (PVs) that inform cancer treatment decisions. Per 2019 ESMO guidelines, many somatic PVs in cancer susceptibility genes warrant confirmatory germline genetic testing (gGT). Approximately 4-40% of patients have somatic PVs meeting...

Abigail Macher, Zi-Han Xiong, Vicky Ro et al. · 0 citations
Open access Sep 2026

Fragmented ownership and multilevel barriers to breast MRI screening among high-risk women: A qualitative study informing development of clinical decision support

Background: Women at high risk for breast cancer include those with pathogenic variants in hereditary breast cancer predisposition genes, high-risk benign breast lesions, or a lifetime risk over 20% based on validated models. Supplemental breast MRI screening improves early detection and reduces interval cancers in hig...

Marlee I. Pincus, Cynthia Law, Vicky Ro et al. · 0 citations

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