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Author

K. Dufault-Thompson

2 papers indexed here

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Open access Aug 2026

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Nucleases are crucial for various bacterial processes, including genome maintenance and host defense. Deoxydinucleases (diDNases), a class of Gram-positive bacteria–specific nucleases associated with mobile genetic elements, are homologous to nanoRNase C (NrnC) in Gram-negative bacteria but exhibit notable differences:...

Sofia Mortensen, Audrey A. Burnim, K. Dufault-Thompson et al. · 0 citations
Open access Sep 2026

LAMBDA: a prophage detection benchmark for genomic language models.

This work introduces LAMBDA, a benchmark designed to rigorously evaluate genome language model embeddings through phage-bacteria sequence discrimination across four categories of increasing complexity: probing tasks, fine-tuning assessments, diagnostic tests, and genome-wide prophage detection.

LeAnn M. Lindsey, Nicole L. Pershing, K. Dufault-Thompson et al. · 0 citations

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