7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson's disease.
PURPOSE Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra (SN). Imaging biomarkers sensitive to nigral pathology are limited. This study evaluated susceptibility changes in the SN using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7...