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Author

K. Forti

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2 papers indexed here

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Sep 2026

Abstract A019: Tumor Nutrient Stress Regulates Cancer-associated Fibroblast Heterogeneity

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer type with a 5-year survival rate of only 13%. PDAC is unique in that up to 90% of the tumor bulk is comprised of a dense desmoplastic stroma. Enriched within PDAC’s extensive stroma are cancer-associated fibroblasts (CAFs). CAFs orchestrate tumor progression...

Marta R. Storl-Desmond, Nicole Liu, K. Forti et al. · 0 citations
Sep 2026

Abstract B008: Pan-RAS-GTP inhibition disrupts the KRAS-SHH axis to reprogram cancer-associated fibroblast subtypes and reduce stiffness in pancreatic cancer

Oncogenic KRAS mutations are present in ∼95% of pancreatic ductal adenocarcinoma (PDAC) cases and have long been considered undruggable. The recent clinical emergence of RAS inhibitors marks a transformative moment in PDAC therapy, yet their impact on the tumor microenvironment (TME) remains largely unknown. This is...

Marie C. Hasselluhn, Allison C. Hess, L. Tomassoni et al. · 0 citations

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