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Open access Oct 2026

Clinical characteristics and severity classification in Mixed Connective Tissue Disease: a nationwide retrospective study.

OBJECTIVES To characterize clinical manifestations, major organ involvement, real-world treatment patterns, and factors associated with severity classification in Japanese patients with mixed connective tissue disease (MCTD), aiming to clarify its heterogeneous clinical spectrum. METHODS This nationwide retrospective...

S. Kubo, Yurie Kanda, Hideto Kameda et al. · 0 citations
Open access Sep 2026

CASTOR1 regulates humoral immune responses and contributes to the pathogenesis of systemic lupus erythematosus.

OBJECTIVES CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. METHODS We analyzed human B cell transcriptomes from healthy controls and patients with systemic lu...

T. Kusuda, T. Komai, T. Itamiya et al. · 0 citations

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