Author

K. Garcia-Mansfield

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Open access Sep 2026

Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-frontotemporal dementia

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are linked neurodegenerative diseases characterized by both synaptic dysfunction and TDP-43 pathology. A hexanucleotide repeat expansion (HRE) in the C9ORF72 (C9) gene represents the most common genetic cause of FTD and ALS, yet the synapse-specific...

A. Spillman, E. Alsop, L. M. Gittings et al. · Acta Neuropathologica · 0 citations

Open access Sep 2026

Serum metabolomics signatures after an acute bout of combined traditional or high‐intensity tactical training in young adults

Alternative exercise prescriptions and doses would be expected to result in distinct signatures due to differences in duration and intensity. We tested two novel combined endurance and resistance exercise regimens to understand how differing prescriptions alter the timecourse of metabolomics response. Serum metabolomic...

Z. Graham, K. Pathak, K. Garcia-Mansfield et al. · Physiological Reports · 0 citations

Open access Sep 2026

A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms

Pathological cardiac fibrosis and hypertrophy, key contributors to adverse remodeling that drives heart failure (HF), are not adequately targeted by current therapies. We identified tRNA-Asp-GTC-3′tDR, an ischemia-induced tRNA-derived small RNA (tDR), as an endogenous regulator of both remodeling processes across cardi...

Tian Hao, Jin Li, Kaushik V. Amancherla et al. · bioRxiv · 0 citations

Open access Jul 2026

Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-Frontotemporal Dementia

Combined multi-omic profiling of synaptosomes enriched from postmortem frontal cortex and patient-derived induced pluripotent stem cell (iPSC)-derived cortical neurons defines convergent molecular pathways underlying synapse vulnerability in both C9-FTD model systems and identifies synaptic localization of CE-containin...

A. Spillman, E. Alsop, L. M. Gittings et al. · bioRxiv · 0 citations

Open access Jul 2026

Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics

This work developed an integrated experimental and computational pipeline for protein-level cell annotation and applied it to human PBMCs as an immune-cell test case, delivering an analytically benchmarked SCP workflow that resolves immune lineage and cell-state heterogeneity in human PBMCs and provides a classifier-re...

S. O'Connor, Romell B. Gletten, Ritin Sharma et al. · bioRxiv · 1 citation