Author

K. Hosomi

2 papers indexed here

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Open access Sep 2026

Multilayered Prioritization of Graph Attention Autoencoder–Derived Drug Repurposing Candidates for COVID-19

Background/Objectives: The COVID-19 pandemic highlighted the critical need for drug repurposing. While computational graph-based approaches show promise, single analytical methods often fail to capture the complex pathological mechanisms needed for clinical translation. We aimed to prioritize COVID-19 repurposing candi...

Yusuke Nakayama, S. Tsuji, Koji Yamamoto et al. · Pharmaceuticals · 0 citations

Sep 2026

Pharmacotherapy of heart failure: Impact of the 2021 guideline update on guideline-directed medical therapy assessed using a Japanese employee health insurance claims database.

The 2021 guideline update was associated with increased use of sacubitril/valsartan and dapagliflozin, resulting in greater overall GDMT intensity, however, these findings are limited to data from 2021, and further long-term studies are needed to evaluate trends in GDMT utilization.

T. Uno, K. Hosomi, S. Yokoyama · International journal of cli... · 0 citations