Author

K. Iskandar

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Jul 2026

Abstract P87: Drug-induced Hyperactivation of the oncogene KRAS induces ferroptosis in G12-mutant KRAS Pancreatic Ductal Adenocarcinoma (PDAC)

C1 is presented as a novel therapeutic agent for KRAS-mutant PDAC and the concept of hyperactivating oncogenic KRAS to selectively induce ferroptotic cancer cell death is introduced.

Haiyuxin Zhu, K. Iskandar, Nur Syafiqah Binte Sulaiman et al. · Cancer Research · 0 citations

Jul 2026

Abstract P106: SELECTIVE CYTOTOXICITY IN KRAS-MUTANT CANCER CELLS THROUGH COORDINATED STABILIZATION OF KRAS AND ITS UPSTREAM REGULATORS USING SMALL MOLECULE DRUG

Results suggest that C1-induced lethality involves coordinated stabilization of multiple upstream KRAS regulators, with GRB2 acting as one component that may amplify signalling in a mutant-specific context, a novel mechanistic axis of synthetic lethality in KRAS-driven cancers.

Benedict J. Leong, K. Iskandar, Liang Ying Yu et al. · Cancer Research · 0 citations