Author

K. Jude

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Open access Sep 2026

MHC restriction is structurally encoded by the T cell receptor germline

MHC restriction — the requirement for αβ T cell receptors (TCRs) to recognize Major Histocompatibility Complex (MHC) molecules when presenting peptide antigens — is a pillar of adaptive immunity. Here, we provide direct structural evidence for TCR germline-encoded recognition of MHC molecules irrespective of antigenic...

Nan Wang, Marta T. Borowska, K. Jude et al. · bioRxiv · 0 citations

Open access Aug 2026

A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function

The extent to which JAK/STAT cytokine signaling is functionally redundant or selective remains debated. Here we engineered a “double” orthogonal IL-2/IL-2Rβ/γc ternary system enabling programmable, interference-free activation of each of the 36 mammalian cytokine receptors, and their downstream six STATs, in T cells. A...

Pingdong Tao, Ruchir Rastogi, Hua Jiang et al. · bioRxiv · 0 citations