Abstract Background Previous retrospective work found an association between earlier immune-checkpoint inhibitors (ICI) infusion times and survival outcomes in renal cell carcinoma (RCC). A recent randomized trial in non-small cell lung cancer (NSCLC) also reported benefit, however, a recent analysis of several randomi...
P. Barrios, Mustafa Saleh, Liliana Ascione et al.· The Oncologist· 0 citations
This scalable method enables derivation of real-world endpoints from EHR-based data and may be used to characterize outcomes for patients treated outside of prospective clinical trials and may inform the creation of synthetic control cohorts to support regulatory approvals for new drugs in rare tumor or biomarker defin...
J. Lavery, Samantha Brown, Chelsea Nichols et al.· Cancer Epidemiology, Biomark...· 0 citations
PanoraOnc enables transferable treatment outcome prediction through pan-cancer pretraining and generalizes to unseen cohorts across cancer types, institutions, and therapeutic settings, demonstrating that large-scale clinico-genomic pretraining enables robust and generalizable outcome predictions across previously unse...
M. Schuerch, J. Geisberg, C. T. Flower et al.· medRxiv· 0 citations
Open-source LLMs, when fine-tuned using labeled data, can effectively automate the ascertainment of key radiophenotypic variables using only the impression section of radiology reports, without the full report text, suggesting that these models may provide a scalable approach for phenotypic characterization of patients...
S. A. Naqvi, I. Riaz, Amir Saeidi et al.· JCO Clinical Cancer Informat...· 0 citations
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