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Review Open access Sep 2026

Efficacy and safety of risk-stratified chemotherapy with azacitidine for children with myeloid leukaemia with Down syndrome: protocol for a multicentre phase II trial (JCCG AML-D24)

Abstract Introduction The prognosis of myeloid leukaemia associated with Down syndrome (ML-DS) is excellent with reduced-intensity chemotherapy; however, that of refractory or relapsed ML-DS remains dismal. These contrasting outcomes highlight the importance of risk-stratified therapy, based on reliable prognostic fact...

Kentaro Nakashima, Daisuke Hasegawa, Jun Matsubayashi et al. · 0 citations
Review Oct 2026

Beyond Reirradiation: Third-Course Radiation Therapy in Recurrent Diffuse Intrinsic Pontine Glioma-Case Series and Literature Review.

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brainstem tumor with a poor prognosis, for which radiotherapy remains the only established treatment. Although reirradiation at first progression has been reported to provide symptomatic relief and survival benefit, the role of a third course of irradiation...

Haruna Sakagami, Koichi Morokawa, Yoshitaka Mizushima et al. · 0 citations

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