K. Korthauer

Cross-platform Bayesian deconvolution of MeDIP-seq reveals tissue-specific and cancer-associated methylation signatures

DNA methylation profiling of cell-free DNA is increasingly used for tissue-of-origin analysis and cancer detection, but quantitative interpretation of enrichment-based sequencing data remains a major challenge. MeDIP-seq provides scalable, cost-effective profiling of low-input samples like cell-free DNA, but lacks...