Author

K. Mackie

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Open access Sep 2026

Morphine causes distinct changes in the lipidome throughout the brain and body after acute or chronic administration: implications for novel endogenous lipid signaling systems involved in opioid reward and withdrawal

T. Woodward, E. Chafee, Evan Cannon et al. · bioRxiv · 0 citations

Open access Aug 2026

State-dependent cannabidiol interactions with fentanyl-bound mouse μ-opioid receptor conformations: a three-state molecular dynamics study

We published recently that one of the main constituents of cannabis products, cannabidiol (CBD), is an efficacious negative allosteric modulator (NAM) of the µ opioid receptor (MOR1) (Bosquez-Berger et al., 2023). Here, we investigated how the presence of cannabidiol (CBD) is associated with fentanyl (FEN) binding acro...

J. Wager-Miller, G. Szanda, A. Straiker et al. · bioRxiv · 0 citations