451. Investigating synaptic density in youth with cannabis use: preliminary findings from a [18F]SynVesT-1 PET imaging study
Abstract Background Adolescence is a key period for neurodevelopment, marked by synaptic pruning. Preclinical studies show that repeated cannabinoid exposure can alter synaptic structure and synaptic protein markers (Oliva et al., 2024; Rubino et al., 2015). In adults, chronic cannabis use has been linked to lower syna...