Platelet peptidylarginine deiminase 4 is not essential for platelet function in homeostasis or fibrosis during normal aging.
BACKGROUND AND OBJECTIVES Fibrotic remodeling is a key feature of cardiac aging and a major contributor to heart failure. The bidirectional interplay between platelets and neutrophil extracellular traps (NETs), with peptidylarginine deiminase 4 (PAD4) facilitating NET formation, has emerged as a mediator of fibrotic re...