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Author

K. Matsushita

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Nov 2026

Abstract 8972: Discovery and Temporal Validation of Proteomic Signatures for Incident Chronic Limb-Threatening Ischemia in the Atherosclerotic Risk in Communities (ARIC) Study

Background: Chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease (PAD) with rest pain, non-healing ulcers, or gangrene, is a devastating condition with high risks of limb loss and mortality. Emerging evidence indicates that CLTI reflects a distinct pathophysiologic state rather than s...

E. Bansah, Xiao Hu, Caitlin W. Hicks et al. · 0 citations
Aug 2026

Metabolites Associated With Long-Term Risk of Peripheral Artery Disease: The ARIC Study.

Distinct metabolomic profiles were associated with incident PAD and CLI years before clinical onset, highlighting dysregulated glycemic control, impaired redox balance, and altered lipid remodeling as key underlying pathways and suggest that circulating metabolites may serve as early indicators of metabolic health rele...

E. Bansah, Xiao Hu, S. Ballew et al. · 0 citations

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