Open access
Sep 2026
Vitamin D Pathway Activation Reduces Cardiomyocyte DNA Damage and Improves Cardiac Contractility in Preclinical Models.
BACKGROUND In heart failure (HF), DNA damage caused by various external stressors contributes to cardiac dysfunction through the activation of DNA damage response pathways. To date, no clinical strategies have been established to restore cardiac function by reducing accumulated DNA damage. We previously found that vita...
Masamichi Ito, Manami Katoh, Masayuki Kubota et al.
· JACC: Advances · 0 citations