Author

K. Mayer-Barber

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Open access Sep 2026

Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure.

Immunosuppressive therapies (ISTs), including calcineurin inhibitors like cyclosporine A (CsA), are essential therapeutics for autoimmunity; however, they often fail and cause dose-limiting toxicity. Severe aplastic anemia (SAA) is a fatal autoimmune bone marrow (BM) failure disorder that is treated with ISTs. BM singl...

Rachel Grazda, Amber Bahr, Lily Nti-kyeremeh et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

Activating Inflammation Resolution Programs Improves Immunosuppressive Therapy and Prevents Toxicity in Autoimmune Bone Marrow Failure 2267406

Co-treatment with RvE1 restores immune and hematopoietic homeostasis, supporting integration of pro-resolving therapy with IST for safer, durable remission for autoimmune and inflammatory diseases.

Rachel Grazda, Amber Bahr, Lily Nti-kyeremeh et al. · Journal of Immunology · 0 citations

Open access Jul 2026

Protein kinase F regulates the virulence of Mycobacterium tuberculosis

The data suggest that expression of PknF, as a modulator of multiple downstream effector proteins, restricts the virulence of Mtb in the lungs of mice through an NLRP3 inflammasome-independent mechanism, but potentially via suppressing production of the virulence lipid, PDIM.

Flor Torres-Juárez, Shivangi Rastogi, David C. Young et al. · Infection and Immunity · 0 citations