ETV6:RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Review
The ETV6:RUNX1 (formerly TEL: AML1) fusion gene resulting from the cryptic translocation t (12;21) (p13; q22) represents the most frequent chimeric oncogene in pediatric B-cell precursor acute lymphoblastic leukemia (B-ALL), accounting for approximately 25% of cases. Typically initiating in utero during fetal hematopoi...