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Author

K. Mohlke

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Open access Aug 2026

Integrated Analysis of Skeletal Muscle Transcriptional Networks Characterizes Dysregulation in Pathways and Trait-Associated Regulatory Regions in Type 2 Diabetes

Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.

A. Maddox, Nandini Manickam, Peter Orchard et al. · 0 citations
Open access Aug 2026

Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells?

It is shown that in muscle and neural cells that have ceased to replicate their chromatin and permanently exited the cell cycle, HLBs are dismantled and NPAT, FLASH and Lsm11 are detected in the cytoplasm, suggesting that in postmitotic cells, NPAT and U7 snRNP become repurposed for functions unrelated to generating hi...

Xiao-cui Yang, Anthony Desotell, Agata Malinowska et al. · 0 citations
Open access Aug 2026

Erosion of regenerative regulation: age-associated shifts in the skeletal muscle fiber epigenome and transcriptome

Together, these findings identify an age-associated regulatory shift, largely invisible in matched transcriptomic data, characterized by closing chromatin which reduces accessibility to hormone receptor binding sites and enhancer regions in the muscle fiber epigenome.

Keagan G. Moo, Peter Orchard, Arushi Varshney et al. · 0 citations

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