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Author

K. Mokgopa

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Open access Aug 2026

Computational Design of RNA Aptamers Targeting Oncogenic miR-10b Using T‑SELEX and Molecular Dynamics-Based Stability Metrics

Aptamers are versatile single-stranded nucleic acids with high specificity and stability, making them ideal for targeting challenging biomolecules. Their structural flexibility enables selective recognition of nonprotein targets such as microRNAs (miRNAs). Among these, miR-10b plays a pivotal role in cancer progression...

K. Mokgopa, Kevin A. Lobb, T. Tshiwawa · 0 citations
Open access Sep 2026

APDB: A Large-Scale Repository of Predicted 2D and 3D Aptamer Structures

RNA aptamers are short, single-stranded oligonucleotides capable of folding into specific three-dimensional structures to bind diverse molecular targets with high affinity and specificity. In this study, we present a comprehensive computational analysis of a curated data set of over 150,000 RNA aptamers annotated with...

K. Mokgopa, Kevin A. Lobb, T. Tshiwawa · 0 citations

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