Reference bias is an issue that affects most genomic studies analysing short reads mapped to a reference genome1,2. It can be mitigated by mapping to multiple haplotypes represented in a pangenome3-5. Here we introduce two new methods to address reference bias: Emblask for pangenome construction and Weaver for mapping...
Guillaume Holley, H. Eggertsson, Snaedis Kristmundsdottir et al.· Nature· 0 citations
23 new Y. pestis genomes recovered from Second Plague Pandemic contexts across Scandinavia, the Netherlands, Iceland, and Armenia are reported and clade-defining mutations are identified, including nonsynonymous changes in metabolic and biofilm-related genes with predicted structural effects that may have contributed t...
Cameron Ferguson, Å. J. Vågene, Marcel Keller et al.· bioRxiv· 1 citation
Analysis of a markedly larger, higher-coverage, and geographically diverse whole-genome sequencing dataset from 529 ancient individuals sheds important light on the demographic impact of major sociohistorical changes that occurred during the late Medieval period in Scandinavia and the Baltic region and link Christianis...
Xiaodong Liu, K. Moore, S. Ebenesersdóttir et al.· 0 citations
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