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Review Open access Sep 2026

Treatment updates in myotonic disorders

Myotonia is delayed muscle relaxation after forceful contraction. It is due to hyperexcitability of the skeletal muscle membrane. It can arise from primary skeletal muscle ion channel dysfunction, involving chloride or sodium channels, but is also a prominent clinical feature in myotonic dystrophies where altered RNA s...

E. Matthews, M. Specterman, K. Mul · 0 citations
Open access Sep 2026

Clinical associations of pain in an international facioscapulohumeral muscular dystrophy cohort.

Pain intensity was associated with all domains, including physical function, anxiety, depression, fatigue, sleep disturbance, and pain interference, whereas binary pain status was associated with worse physical function, fatigue, sleep disturbance, and pain interference.

Renatta N. Knox, Leo H. Wang, B. Elsheikh et al. · 0 citations

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