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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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K. Nakagawa

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Sep 2026

An Investigation of Water Vapor Sorption for Improving Reconstitution Pathways of Freeze-Dried Lipid Nanoparticles Stabilized by Trehalose/Mannitol Excipients

A practical suggestion would be to use a formulation of trehalose and mannitol mixture, allow it to absorb water vapor until the glass–rubber transition, and rehydrate before the crystallization of trehalose, which would be an appropriate reconstitution path to allow the LNP to be retained its original formation.

K. Nakagawa, Yuji Senga · 0 citations

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