Abstract INTRODUCTION Adherence to the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with reduced dementia risk, but underlying mechanisms remain unclear. METHODS Plasma proteomics (SomaScan 7k) from 206 Indiana Alzheimer's Disease Research Cent...
Shane Fernandez, Desarae A. Dempsey, Soumilee Chaudhuri et al.· Alzheimer's & Dementia· 0 citations
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain prot...
Sang-Won Han, Young Ho Park, Jung-Min Pyun et al.· Alzheimer's & Dementia· 0 citations
This work model AD progression as a deviation from aging using longitudinal amyloid PET and a self-supervised trajectory-learning framework and reveals a shared early path that bifurcated into an aging branch and an AD-related branch.
The impact of CKD transcriptional risk on AD endophenotypes is assessed by assessing the impact of CKD transcriptional risk on AD endophenotypes in individuals with chronic kidney disease.
Jung-Min Pyun, Young Ho Park, Jiyun Hwang et al.· Alzheimer's & Dementia· 0 citations
Alzheimer's disease (AD) arises from heterogeneous biological processes, and long‐term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.
BoHung Kim, Hyunwoo Lee, Junpyo Kim et al.· Alzheimer's & Dementia· 0 citations
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