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K. Nonchev

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Open access Oct 2026

Slide-level batch structure limits histology-guided supervision of transcriptomic foundation models

Spatial transcriptomics pairs spatially resolved gene expression with tissue morphology in the same tissue section. Transcriptomic foundation models encode such expression profiles into general-purpose representations, but these representations can retain slide- and cohort-specific variation that obscures biological si...

Ulysse McConnell, K. Nonchev, V. Koelzer et al. · 0 citations

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