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Open access Sep 2026

Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes

ABSTRACT Background Heterozygous pathogenic variants in COL4A3 or COL4A4 are relatively common and associated with a broad clinical spectrum. However, nomenclature and risk stratification remain unsettled. We aimed to investigate temporal diagnostic trends and clinical features of haematuria-positive individuals with h...

Yuriko Tanaka, T. Horinouchi, Shuhei Aoyama et al. · 0 citations
Oct 2026

Response to: "Early benzodiazepine treatment and electrographic seizures after febrile status epilepticus".

We appreciate Inui et al.'s comments regarding the divergent prognostic outcomes of patients with electrographic seizures (ESz) between our studies. The poorer prognosis in their cohort compared to ours likely stems from three key differences. First, baseline disease severity significantly differed. Our cohort predomin...

Kento Souma, Hiroshi Yamaguchi, Takuya Ueda et al. · 0 citations
Sep 2026

Reduced-lead electroencephalography performed at the discretion of emergency physicians in pediatric cases of altered mental status: A retrospective observational study.

BACKGROUND Altered mental status (AMS) is frequently encountered among children in emergency departments (ED) and represents a nonspecific manifestation of brain dysfunction. However, the extent to which reduced-lead electroencephalography (EEG) findings obtained and interpreted by ED physicians influence treatment dec...

Hiroshi Yamaguchi, Azusa Maruyama, Takuya Ueda et al. · 1 citation

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