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Open access Aug 2026

Expanding the phenotype of hereditary renal cell carcinoma syndromes: Implications for surveillance and management.

BACKGROUND Approximately 5% of renal cell carcinoma (RCC) occurs in the setting of a hereditary RCC syndrome, but accurate phenotype and cancer risk estimates remain limited by ascertainment bias in reported series. METHODS We analyzed 32,728 cancer patients who underwent paired tumor-normal sequencing with MSK-IMPAC...

M. Carlo, Andrew Schroeder, Jie Liu et al. · 0 citations
Meta-analysis Open access Aug 2026

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.

L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al. · 0 citations

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