Patient-specific stopping power calibration of treatment planning x-ray CT using integrated depth-dose profiles acquired by proton transmission imaging—a feasibility study
Objective. Range uncertainties in proton therapy largely arise from the semi-empirical conversion of x-ray computed tomography (CT) Hounsfield Units to stopping power relative to water (RSP), requiring generous safety margins or robust optimization. Pencil beam-wise integrated depth-dose profiles (IDDs), obtained via p...