Genotoxic chemotherapies are central components of the treatment regimen for most cancers but are rarely curative. Drug-tolerant persister cells (DTPs) evade cell death during these treatments by accessing transient adaptive states and can contribute to cancer progression after treatment. Here, we demonstrate that ca...
Kevin Truskowski, Louis T. A. Rolle, Bo-Wen Wang et al.· Cell Death & Disease· 0 citations
Most cancer deaths result from metastasis, yet only a subset of tumor cells can complete this process. Polyaneuploid cancer cells (PACCs), which arise via endoreplication under stressors such as hypoxia, are implicated as metastatic drivers, but how they acquire this capacity remains unclear. Here, we show that under e...
Noreen Hosny, Shengkai Li, Robert Gatenby et al.· Biophysical Journal· 0 citations
Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation o...
Mehreen Ahmed, A. Al-haidari, S. Agarwal et al.· Signal Transduction and Targ...· 0 citations
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