Open access
Aug 2026
Early pre-symptomatic and sex-specific cardiac remodeling precedes heart failure in zebrafish with human actin mutation.
It is demonstrated that the Acta1b p.T126I mutation drives progressive, sex-specific DCM in zebrafish, highlighting biological sex as a critical modifier of sarcomeric cardiomyopathy progression and targeted therapy development.
K. Prill, John F. Dawson
· Disease Models & Mechanisms · 0 citations